BDBM289666 8-(3-Chlorobenzyl)-6-(3,4-dimethoxybenzyl)-8,9,10,11-tetrahydropyrido[3',2':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one::US10092575, Example 155::US10376514, Example 155

SMILES COc1ccc(Cn2c3sc4N(Cc5cccc(Cl)c5)CCCc4c3c3ncnn3c2=O)cc1OC

InChI Key InChIKey=IJPNTJFSFUIZOQ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289666   

LigandChemical structure of BindingDB Monomer ID 289666BDBM289666(8-(3-Chlorobenzyl)-6-(3,4-dimethoxybenzyl)-8,9,10,...)
Affinity DataEC50:  5.50E+3nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 289666BDBM289666(8-(3-Chlorobenzyl)-6-(3,4-dimethoxybenzyl)-8,9,10,...)
Affinity DataIC50: 5.50E+3nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 289666BDBM289666(8-(3-Chlorobenzyl)-6-(3,4-dimethoxybenzyl)-8,9,10,...)
Affinity DataIC50: 5.50E+3nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent