BDBM289684 9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-6,8,9,10,11,12-hexahydro-5H-[1,2,4]triazolo[1 ,5 :1',6']pyrimido[5',4':4,5]thieno[2,3-c]azepin-5-one::US10092575, Example 173::US10376514, Example 173

SMILES COc1ccc(Cn2c3sc4CN(CCCc4c3c3ncnn3c2=O)C(=O)C2CC2)cc1

InChI Key InChIKey=IFGXUCPRAVAEDN-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289684   

LigandPNGBDBM289684(9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-6,8,9...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent

LigandPNGBDBM289684(9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-6,8,9...)
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM289684(9-(Cyclopropanecarbonyl)-6-(4-methoxybenzyl)-6,8,9...)
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
US Patent