BDBM289901 2-Methyl-1-(4-{6-[5-(2H-pyrazol-3- yl)-pyrimidin-2-yloxy]-naphthalen-2- ylmethyl}-piperazin-1-yl)-propan-1-one::US9573957, Example 41

SMILES CC(C)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(-c5ccn[nH]5)cn4)ccc3c2)CC1

InChI Key InChIKey=LSAGIKCWXLDSFY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289901   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 289901BDBM289901(2-Methyl-1-(4-{6-[5-(2H-pyrazol-3- yl)-pyrimidin-2...)
Affinity DataIC50: 0.970nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent