BDBM290041 US9573961, Example 26

SMILES COc1ccc([C@@H]2CN3CCN(C[C@H]3CO2)C(=O)Cc2ccc(cc2)-n2cnnn2)c(C)c1C#N

InChI Key InChIKey=ASSSKZFDXANIRZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290041   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM290041(US9573961, Example 26)
Affinity DataIC50: 140nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent