BDBM290161 US9573958, Compound 115

SMILES CC(C)(C)CNCc1ccc2nc(NC(=O)c3ccc(s3)C(F)F)n(C[C@H]3CCCN3C(=O)C(=CC3(C)COC3)C#N)c2c1

InChI Key InChIKey=YPALOWSXANXYME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290161   

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290161(US9573958, Compound 115)
Affinity DataIC50: 14.5nMpH: 7.5Assay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent