BDBM290217 US9573958, Compound 58

SMILES C[C@H](NCc1ccc2n(C[C@H]3CCCN3C(=O)C=C)c(NC(=O)c3ccc(Cl)cc3)nc2c1)C(C)(C)C

InChI Key InChIKey=BEDWKJCGDZYRIO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290217   

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM290217(US9573958, Compound 58)
Affinity DataIC50: 7nMpH: 7.5Assay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent