BDBM290892 5-(fluoro-methyloxy- d2)-1-(2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl)- 3-(1-phenyl-1H- pyrazol-5- yl)pyridazin-4(1H)- one::US9579407, Example 00163

SMILES [2H]C([2H])(F)Oc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)C1CCOCC1

InChI Key InChIKey=DAKOIZUHYLSQDY-BPPAMHLBSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290892   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM290892(US9579407, Example 00163 | 5-(fluoro-methyloxy- d2...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Human PDE1A, 3A, 4D2, 5A1, 7B, 8A1, 9A2, and 11A4 enzymes were purchased from BPS Bioscience. Human PDE6AB enzyme was purchased from Scottish Biomedi...More data for this Ligand-Target Pair
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Date in BDB:
2/19/2019
Entry Details
US Patent