BDBM291495 1-((3S,4S)-4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-3-hydroxypiperidin-1-yl)but-2-yn-1-one ::US10413562, Compound A215::US9580449, Example A215

SMILES CC#CC(=O)N1CC[C@@H](CNc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)[C@H](O)C1

InChI Key InChIKey=JXIYKFLNPXQSQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291495   

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291495(1-((3S,4S)-4-(((6-amino-5-(4-phenoxyphenyl)pyrimid...)
Affinity DataIC50: 100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Patent

US Patent
LigandPNGBDBM291495(1-((3S,4S)-4-(((6-amino-5-(4-phenoxyphenyl)pyrimid...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2019
Entry Details
US Patent