BDBM291912 (4-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-1-methyl-1H-pyrazol-5-yl)methanol::US11207325, Example 227::US9580437, Example 227

SMILES Cn1ncc(c1CO)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=OXICPRAQBJWTNI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291912   

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291912BDBM291912(US9580437, Example 227 | (4-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 6.10nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291912BDBM291912(US9580437, Example 227 | (4-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 6.10nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291912BDBM291912(US9580437, Example 227 | (4-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 7.5nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291912BDBM291912(US9580437, Example 227 | (4-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 7.5nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291912BDBM291912(US9580437, Example 227 | (4-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 9.10nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291912BDBM291912(US9580437, Example 227 | (4-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 9.10nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent