BDBM291930 8-(1,2-dimethyl-1H-imidazol-5-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-::US11207325, Example 245::US9580437, Example 245

SMILES Cc1ncc(-c2cnc(NCc3c4CCOc4ccc3F)n3cnnc23)n1C

InChI Key InChIKey=BPVVBXTWDZKTIU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291930   

LigandChemical structure of BindingDB Monomer ID 291930BDBM291930(US9580437, Example 245 | 8-(1,2-dimethyl-1H-imidaz...)
Affinity DataIC50: 67.2nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291930BDBM291930(US9580437, Example 245 | 8-(1,2-dimethyl-1H-imidaz...)
Affinity DataIC50: 67.2nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291930BDBM291930(US9580437, Example 245 | 8-(1,2-dimethyl-1H-imidaz...)
Affinity DataIC50: 223nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291930BDBM291930(US9580437, Example 245 | 8-(1,2-dimethyl-1H-imidaz...)
Affinity DataIC50: 223nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent