BDBM292080 4-{5-[1-(cyclopropylmethyl)-1H-pyrazol-4- yl]-2-{decahydropyrrolo[3,4-d]azepin-6- yl}-1,3-thiazol-4-yl]benzonitrile::US10100046, Example 15::US9902719, Example 15

SMILES N#Cc1ccc(cc1)-c1nc(sc1-c1cnn(CC2CC2)c1)N1CC[C@@H]2CNC[C@@H]2CC1

InChI Key InChIKey=LIEGLPZXWIKCQW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292080   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292080(US10100046, Example 15 | 4-{5-[1-(cyclopropylmethy...)
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM292080(US10100046, Example 15 | 4-{5-[1-(cyclopropylmethy...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent