BDBM292137 2-(5-hydroxy-2-phenoxy-1,7-naphthyridine-6-formamido) acetic acid::US10100051, Compound 6::US11981669, Comparative Example 2

SMILES OC(=O)CNC(=O)c1ncc2nc(Oc3ccccc3)ccc2c1O

InChI Key InChIKey=BNGUFHNMUNKJQI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 292137   

TargetProlyl hydroxylase EGLN2(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM292137(US10100051, Compound 6 | 2-(5-hydroxy-2-phenoxy-1,...)
Affinity DataIC50: 335nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetProlyl hydroxylase EGLN3(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM292137(US10100051, Compound 6 | 2-(5-hydroxy-2-phenoxy-1,...)
Affinity DataIC50: 492nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetEgl nine homolog 1(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM292137(US10100051, Compound 6 | 2-(5-hydroxy-2-phenoxy-1,...)
Affinity DataIC50: 807nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetEgl nine homolog 1(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM292137(US10100051, Compound 6 | 2-(5-hydroxy-2-phenoxy-1,...)
Affinity DataIC50: 6.90E+3nMT: 2°CAssay Description:To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent