BDBM292225 US10100057, Example 80::US11046702, Example 80::US9745310, Example 80

SMILES Fc1cccc(OCc2cn3cc(cnc3n2)-c2ccc(nc2)C(F)(F)F)c1

InChI Key InChIKey=VREYAGREWZJHPE-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 292225   

TargetMetabotropic glutamate receptor 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM292225(US10100057, Example 80 | US9745310, Example 80 | U...)
Affinity DataEC50: <100nMT: 2°CAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM292225(US10100057, Example 80 | US9745310, Example 80 | U...)
Affinity DataEC50: <100nMAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2021
Entry Details
US Patent

TargetMetabotropic glutamate receptor 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM292225(US10100057, Example 80 | US9745310, Example 80 | U...)
Affinity DataEC50: <100nMAssay Description:Ca2+ (calcium) influx assay is an experiment for measuring the activity of a positive allosteric modulator of mGluR5 receptor in which human mGluR5 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent