BDBM292740 US10106501, Example B-17

SMILES Cc1ccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1

InChI Key InChIKey=HZQVQSYHKFSYGV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292740   

TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292740BDBM292740(US20260014133, Compound 1)
Affinity DataEC50:  105nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetDNA damage-binding protein 1/Protein cereblon(Human)
St. Jude''s Chidren''s Research Hospital, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 292740BDBM292740(US20260014133, Compound 1)
Affinity DataIC50: 5.50E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2026
Entry Details US Patent