BDBM292743 US10106501, Example B-20

SMILES O=C1CCC(N2Cc3cc(NC(=O)c4ccccc4)ccc3C2=O)C(=O)N1

InChI Key InChIKey=IZDUHYXDAPGFQI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292743   

TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292743BDBM292743(US20260014133, Compound 4)
Affinity DataEC50:  127nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetDNA damage-binding protein 1/Protein cereblon(Human)
St. Jude''s Chidren''s Research Hospital, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 292743BDBM292743(US20260014133, Compound 4)
Affinity DataIC50: 1.00E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2026
Entry Details US Patent