BDBM292748 US10106501, Example B-25

SMILES N#Cc1cccc(C(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1

InChI Key InChIKey=AZDFVUILZYVTKM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292748   

TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292748BDBM292748(US20260014133, Compound 9)
Affinity DataEC50:  489nMAssay Description:Inhibition of PLK4 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetDNA damage-binding protein 1/Protein cereblon(Human)
St. Jude''s Chidren''s Research Hospital, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 292748BDBM292748(US20260014133, Compound 9)
Affinity DataIC50: 1.00E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2026
Entry Details US Patent