BDBM292938 US10105367, Example 224::US10376514, Example 224

SMILES CCC1CN(Cc2cnc3n(Cc4ccc(OC)cc4)c(=O)n4ncnc4c3c2)CCO1

InChI Key InChIKey=ROTNPJUKGYGBRP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292938   

LigandPNGBDBM292938(US10105367, Example 224 | US10376514, Example 224)
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
US Patent

LigandPNGBDBM292938(US10105367, Example 224 | US10376514, Example 224)
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent