BDBM293353 US10106508, Compound I-22::US10106508, Example 22 N-(4-Chloro-3-fluorophenyl)-5-(tetrahydro-2H-pyran-4-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]-quinazolin-10-amine (I-22)

SMILES Fc1cc(Nc2ncnc3cc(OC4CCOCC4)c4OCCOc4c23)ccc1Cl

InChI Key InChIKey=MHEIKVUKMGZIBT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 293353   

TargetEpidermal growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293353(US10106508, Compound I-22 | US10106508, Example 22...)
Affinity DataIC50: 100nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293353(US10106508, Compound I-22 | US10106508, Example 22...)
Affinity DataIC50: 1.00E+3nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent