BDBM293354 US10106508, Compound I-23::US10106508, Example 23 N-(4-Chloro-3-fluorophenyl)-5-(tetrahydrofuran-3-yloxy)-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-amine (I-23)

SMILES Fc1cc(Nc2ncnc3cc(OC4CCOC4)c4OCCOc4c23)ccc1Cl

InChI Key InChIKey=BEWVMHUKVXCLGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 293354   

TargetEpidermal growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293354(US10106508, Compound I-23 | US10106508, Example 23...)
Affinity DataIC50: 50nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM293354(US10106508, Compound I-23 | US10106508, Example 23...)
Affinity DataIC50: 100nMAssay Description:The sample compounds were dissolved in DMSO and diluted it to 500 μM concentration with DMSO and transferred to a dose plate. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
US Patent