BDBM29392 tacrine-dihydropyridine hybrid (tacripyrine), 3

SMILES CCOC(=O)C1C(c2ccccc2C(F)(F)F)c2c(N)c3CCCCc3nc2N=C1C

InChI Key InChIKey=JDGLNHITSICCJM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29392   

TargetAcetylcholinesterase(Homo sapiens (Human))
Csic

LigandPNGBDBM29392(tacrine-dihydropyridine hybrid (tacripyrine), 3)
Affinity DataIC50:  226nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards hAChE was determined following the method of Ellman using AChE from human serum and acetylthiocholin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Csic

LigandPNGBDBM29392(tacrine-dihydropyridine hybrid (tacripyrine), 3)
Affinity DataIC50:  210nMAssay Description:The inhibitory activity of the compounds towards AChE was determined following the spectrophotometric method of Rappaport using purified AChE from Ee...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Csic

LigandPNGBDBM29392(tacrine-dihydropyridine hybrid (tacripyrine), 3)
Affinity DataIC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:The inhibitory activity of the compounds towards BuChE was determined following the method of Ellman using BuChE from human serum and butyrylthiochol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed