BDBM294356 US9586950, 23::methyl 4-cyano-2-({(3R,6R)-1-[(5- fluoro-2-pyrimidin-2- ylphenyl)carbonyl]-6- methylpiperidin-3-yl}oxy)pyridine- 3-carboxylate

SMILES COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2cc(F)ccc2-c2ncccn2)nccc1C#N

InChI Key InChIKey=CFIVHPFEXDKGAZ-CRAIPNDOSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 294356   

TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM294356(US9586950, 23 | methyl 4-cyano-2-({(3R,6R)-1-[(5- ...)
Affinity DataKi:  0.470nMAssay Description:Described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM294356(US9586950, 23 | methyl 4-cyano-2-({(3R,6R)-1-[(5- ...)
Affinity DataKi:  46nMAssay Description:Described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM294356(US9586950, 23 | methyl 4-cyano-2-({(3R,6R)-1-[(5- ...)
Affinity DataIC50:  32nMAssay Description:. In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM294356(US9586950, 23 | methyl 4-cyano-2-({(3R,6R)-1-[(5- ...)
Affinity DataIC50:  417nMAssay Description:. In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent