BDBM294479 N-(3-((2-((6-(4-methylpiperazin-1-yl)pyridin- 3-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4- yl)oxy)phenyl)acrylamide::US9586965, Cpd 2

SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cn1

InChI Key InChIKey=PEOCEMXAFXTVAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 294479   

TargetTyrosine-protein kinase JAK3(Human)
Acea Biosciences

US Patent
LigandPNGBDBM294479(US9586965, Cpd 2 | N-(3-((2-((6-(4-methylpiperazin...)
Affinity DataIC50: 0.0365nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Acea Biosciences

US Patent
LigandPNGBDBM294479(US9586965, Cpd 2 | N-(3-((2-((6-(4-methylpiperazin...)
Affinity DataIC50: 0.362nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Acea Biosciences

US Patent
LigandPNGBDBM294479(US9586965, Cpd 2 | N-(3-((2-((6-(4-methylpiperazin...)
Affinity DataIC50: 2.06E+3nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Acea Biosciences

US Patent
LigandPNGBDBM294479(US9586965, Cpd 2 | N-(3-((2-((6-(4-methylpiperazin...)
Affinity DataIC50: 1.40E+4nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent