BDBM294917 2-(4,6-Dimethylpyrimidin-2-yl)-5-{[4-fluoro-2-(4-fluoro-1H-pyrazol-5-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole::US9586962, Example 473

SMILES Cc1cc(C)nc(n1)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-c1[nH]ncc1F

InChI Key InChIKey=BNMXKJWEWITKTJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 294917   

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294917(US9586962, Example 473 | 2-(4,6-Dimethylpyrimidin-...)
Affinity DataKi:  6nM ΔG°:  -11.2kcal/moleT: 2°CAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294917(US9586962, Example 473 | 2-(4,6-Dimethylpyrimidin-...)
Affinity DataKi:  397nM ΔG°:  -8.73kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent