BDBM294918 2-(4,6-Dimethylpyrimidin-2-yl)-5-{[3-fluoro-2-(4-fluoro-1H-pyrazol-5-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole::US9586962, Example 474

SMILES Cc1cc(C)nc(n1)N1CC2CN(CC2C1)C(=O)c1cccc(F)c1-c1[nH]ncc1F

InChI Key InChIKey=KPIGJXMNYXKMSQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 294918   

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294918(US9586962, Example 474 | 2-(4,6-Dimethylpyrimidin-...)
Affinity DataKi:  13nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294918(US9586962, Example 474 | 2-(4,6-Dimethylpyrimidin-...)
Affinity DataKi:  1.32E+3nM ΔG°:  -8.01kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent