BDBM294920 2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(1,3-thiazol-2-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole::US9586962, Example 476

SMILES Cc1cc(C)nc(n1)N1CC2CN(CC2C1)C(=O)c1c(F)cccc1-c1nccs1

InChI Key InChIKey=YZCUBPKTIWQEBT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 294920   

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294920(US9586962, Example 476 | 2-(4,6-Dimethylpyrimidin-...)
Affinity DataKi:  15nM ΔG°:  -10.7kcal/moleT: 2°CAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294920(US9586962, Example 476 | 2-(4,6-Dimethylpyrimidin-...)
Affinity DataKi:  1.39E+3nM ΔG°:  -7.98kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent