BDBM295034 US10112926, Example 4.2::trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H- pyrazol-4-yl)pyridin-3- yl)-N-(4-hydroxy cyclohexyl)-4-methyl- benzenesulfonamide

SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(CC(F)(F)F)c1)S(=O)(=O)N[C@H]1CC[C@H](O)CC1

InChI Key InChIKey=RCBNWWLBZCYILT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 295034   

LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 8nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 380nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 900nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 1.30E+3nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295034(trans 3-(6-Amino-5-(1- (2,2,2-trifluoro ethyl)-1H-...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent