BDBM295219 3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N-((1r,4r)-4-hydroxycyclohexyl)-4-methylbenzenesulfonamide::US10112926, Example 97

SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](O)CC1

InChI Key InChIKey=FFRDFQZNAIEKKG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 295219   

LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 12nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 160nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 520nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 1.34E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 3.80E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandPNGBDBM295219(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Affinity DataIC50: 6.50E+3nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent