BDBM295962 4-{2-methoxy- 4-[2-(3- methoxyphenyl) pyrrolidine- 1-carbonyl] phenyl}- 1H-pyrazole::US10112939, Example 11::US10112939, Example 12::US10112939, Example 4

SMILES COc1cccc(c1)C1CCCN1C(=O)c1ccc(-c2cn[nH]c2)c(OC)c1

InChI Key InChIKey=BHXVSMHUOZGMQI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 295962   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295962(US10112939, Example 4 | US10112939, Example 11 | U...)
Affinity DataIC50: 12.6nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295962(US10112939, Example 4 | US10112939, Example 11 | U...)
Affinity DataIC50: 31.8nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295962(US10112939, Example 4 | US10112939, Example 11 | U...)
Affinity DataIC50: 1.63E+3nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent