BDBM295974 3-{1-[3-methoxy- 4-(1H-pyrazol- 4-yl) benzoyl] pyrrolidin-2- yl}benzene- 1-sulfonamide::US10112939, Example 16::US10112939, Example 17::US10112939, Example 18

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CCCC1c1cccc(c1)S(N)(=O)=O

InChI Key InChIKey=QBHAFMMAFKFIJC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 295974   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295974(US10112939, Example 16 | 3-{1-[3-methoxy- 4-(1H-py...)
Affinity DataIC50: 2.79nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295974(US10112939, Example 16 | 3-{1-[3-methoxy- 4-(1H-py...)
Affinity DataIC50: 3.57nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295974(US10112939, Example 16 | 3-{1-[3-methoxy- 4-(1H-py...)
Affinity DataIC50: 1.28E+3nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent