BDBM295995 3-{1-[3-methoxy-4-(1H- pyrazol-4-yl)benzoyl] pyrrolidin-2-yl}-N-(1- methylpiperidin-4- yl)benzamide::US10112939, Example 36::US10112939, Example 37::US10112939, Example 38

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CCCC1c1cccc(c1)C(=O)NC1CCN(C)CC1

InChI Key InChIKey=ILWCUFAUEUELJF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 295995   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295995(US10112939, Example 36 | 3-{1-[3-methoxy-4-(1H- py...)
Affinity DataIC50: 1.53nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295995(US10112939, Example 36 | 3-{1-[3-methoxy-4-(1H- py...)
Affinity DataIC50: 2.13nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM295995(US10112939, Example 36 | 3-{1-[3-methoxy-4-(1H- py...)
Affinity DataIC50: 751nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent