BDBM296012 3-[(2R)-4-hydroxy-1-[3- methoxy-4-(1H-pyrazol- 4-yl)benzoyl]pyrrolidin- 2-yl]-N-(propan-2- yl)benzamide::US10112939, Example 52

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CC(O)C[C@@H]1c1cccc(c1)C(=O)NC(C)C

InChI Key InChIKey=GLPPVGSAKCYKGI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296012   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296012(US10112939, Example 52 | 3-[(2R)-4-hydroxy-1-[3- m...)
Affinity DataIC50: 6.68nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent