BDBM296024 N-{[2-fluoro-4- (trifluoromethyl)phenyl] methyl}-3-[(2R)-4- hydroxy-1-[3-methoxy-4- (1H-pyrazol-4- yl)benzoyl]pyrrolidin-2- yl]benzamide::US10112939, Example 63

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CC(O)C[C@@H]1c1cccc(c1)C(=O)NCc1ccc(cc1F)C(F)(F)F

InChI Key InChIKey=FDPAMZALCWZLOA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296024   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296024(US10112939, Example 63 | N-{[2-fluoro-4- (trifluor...)
Affinity DataIC50: 5.25nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent