BDBM296046 US10112939, Example 86

SMILES COC1C[C@@H](N(C1)C(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1cccc(c1)C(=O)NCC1CC1

InChI Key InChIKey=WHJXOZHNNWZUNL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296046   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296046(US10112939, Example 86)
Affinity DataIC50: 5.42nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent