BDBM296048 US10112939, Example 88

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1C[C@](C)(O)C[C@@H]1c1cccc(c1)C(=O)NCC1CC1

InChI Key InChIKey=AUZCFLDSZLCQOT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296048   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296048(US10112939, Example 88)
Affinity DataIC50: 10.6nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent