BDBM296055 (3S,5R)-1-[3-(Difluoromethoxy)-4-(1H-pyrazol-4-yl)benzoyl]-5-(2-fluorophenyl)pyrrolidin-3-ol::US10112939, Example 95

SMILES O[C@H]1C[C@@H](N(C1)C(=O)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1)c1ccccc1F

InChI Key InChIKey=MMSZAUREYPKNNE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 296055   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296055(US10112939, Example 95 | (3S,5R)-1-[3-(Difluoromet...)
Affinity DataIC50: 28.4nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296055(US10112939, Example 95 | (3S,5R)-1-[3-(Difluoromet...)
Affinity DataIC50: 44.1nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent