BDBM296066 (3S,5R)-5-(2-Fluorophenyl)-1-[3-methoxy-4-(1H-pyrazol-4-yl)benzoyl] pyrrolidin-3-amine::US10112939, Example 106

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1C[C@@H](N)C[C@@H]1c1ccccc1F

InChI Key InChIKey=RNRNUGODTJKSIF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296066   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM296066(US10112939, Example 106 | (3S,5R)-5-(2-Fluoropheny...)
Affinity DataIC50: 0.870nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent