BDBM297557 2-({2-(1-fluoro-cyclobutyl)-4-[4- (2-methoxy-phenyl)-piperidin-1- yl]-quinazolin-6-yl}-methyl- amino)-ethanol::US10118902, Example 59::US10584103, Example 59

SMILES COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CCC1

InChI Key InChIKey=MMDSVKYAQRIDEA-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 297557   

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM297557(US10118902, Example 59 | 2-({2-(1-fluoro-cyclobuty...)
Affinity DataEC50:  270nMAssay Description:Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated be...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM297557(US10118902, Example 59 | 2-({2-(1-fluoro-cyclobuty...)
Affinity DataEC50: <500nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetNeurotensin receptor type 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM297557(US10118902, Example 59 | 2-({2-(1-fluoro-cyclobuty...)
Affinity DataEC50: <500nMAssay Description:NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent