BDBM298475 US10125101, Example 25

SMILES OC(=O)[C@H]1C[C@@H]1c1ccc(N[C@@H]2CCc3c2c(F)ccc3-c2ccccc2C2(CC2)C#N)cn1

InChI Key InChIKey=SNBLXZKMACCRAA-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 298475   

TargetFree fatty acid receptor 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298475(US10125101, Example 25)
Affinity DataEC50:  344nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298475(US10125101, Example 25)
Affinity DataIC50: 4.00E+4nMAssay Description:The inhibition of cytochrome P450 2C9-isoenzyme catalyzed hydroxylation of diclofenac by the test compound is assayed at 37° C. with human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM298475(US10125101, Example 25)
Affinity DataIC50: 4.90E+4nMAssay Description:The inhibition of cytochrome P450 2C8-isoenzyme catalyzed deethylation of amodiaquine by the test compound is assayed at 37° C. with human liver micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent