BDBM299120 (6S,8R)-6-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)-2-methoxyphenyl)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline::US10125135, Example 9

SMILES COc1cc(OCCN2CC(CF)C2)ccc1[C@H]1N(CC(C)C)[C@H](C)Cc2c1ccc1[nH]ncc21

InChI Key InChIKey=OPSAUQHMFDUBTB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 299120   

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299120(US10125135, Example 9 | (6S,8R)-6-(4-(2-(3-(fluoro...)
Affinity DataIC50: 0.501nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299120(US10125135, Example 9 | (6S,8R)-6-(4-(2-(3-(fluoro...)
Affinity DataIC50: 5.80nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299120(US10125135, Example 9 | (6S,8R)-6-(4-(2-(3-(fluoro...)
Affinity DataIC50: 7.90nMAssay Description:Displacement of fluormone ES2 green reagent from human GST-tagged ERalpha LBD (282 to 595 residues) expressed in baculovirus infected insect cells in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed