BDBM299131 (6S,8R)-7-(2,3- difluoro-2- methylpropyl)-6- (4-(2-(3- (fluoromethyl) azetidin-1- yl)ethoxy)-2- methoxyphenyl)- 8-methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 20::US10125135, Example 21

SMILES COc1cc(OCCN2CC(CF)C2)ccc1[C@H]1N(CC(C)(F)CF)[C@H](C)Cc2c1ccc1[nH]ncc21

InChI Key InChIKey=FUAJAPCMVVAVNQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299131   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299131(US10125135, Example 20 | (6S,8R)-7-(2,3- difluoro-...)
Affinity DataIC50: 1.10nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299131(US10125135, Example 20 | (6S,8R)-7-(2,3- difluoro-...)
Affinity DataIC50: 2nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent