BDBM299140 (6R,8R)-7-((1- fluorocyclo- propyl)methyl)- 6-(4-(2-(3- (fluoromethyl) azetidin-1- yl)ethoxy) phenyl)-8- methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 29

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC1(F)CC1)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=HTTYOIPQUZXZJO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299140   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299140(US10125135, Example 29 | (6R,8R)-7-((1- fluorocycl...)
Affinity DataIC50: 9.20nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent