BDBM299158 3,5-difluoro-4- ((6S,8R)-7-(2- fluoro-2- methylpropyl)-8- methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinolin-6- yl)-N-(2-(3- (fluoromethyl) azetidin-1- yl)ethyl)aniline::US10125135, Example 47

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(C)(C)F)c1c(F)cc(NCCN2CC(CF)C2)cc1F

InChI Key InChIKey=DHPSCKATTRMLKK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299158   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM299158(US10125135, Example 47 | 3,5-difluoro-4- ((6S,8R)-...)
Affinity DataIC50: 1.10nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent