BDBM300951 N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine::US10131663, Example 17

SMILES C[C@H](Cc1cccc(N)c1C)NC(=O)C(F)(F)F

InChI Key InChIKey=MHTDCZHUHNZKNA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 300951   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM300951(N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-m...)
Affinity DataIC50: 0.160nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM300951(N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-m...)
Affinity DataIC50: 2.40nMAssay Description:The assay principle is that ER alpha-LBD (GST) is added to a fluorescent ligand to form a receptor/fluorophore complex. A terbium-labelled anti-GST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM300951(N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-m...)
Affinity DataIC50: 2.20E+4nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent