BDBM301033 4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3- ylmethyl]amino}pyrimidin-4- yl]benzonitrile::US10131664, Example 26::US10543198, Example 26

SMILES N#Cc4ccc(c2nc(NC[C@H]1CCNC1)ncc2C#CC3CC3)cc4

InChI Key InChIKey=SVPNKQAIOZSQML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 301033   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301033(4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301033(4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent