BDBM301045 4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,2-c]pyridin-5- yl}pyrimidin-4-yl]benzonitrile::US10131664, Example 38::US10543198, Example 38::US10864202, Example 38

SMILES Cc5ccc(c3cnc(N2CCC1NCCC1C2)nc3c4ccc(C#N)cc4)cc5

InChI Key InChIKey=ANPYWBRCPZBYMQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 301045   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301045(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,2...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301045(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,2...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM301045(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,2...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent