BDBM301242 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxyethyl)-1,3,4,7-tetrahydro-2H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-2-one::US10131667, Example 58::US11053246, Example 58::US9611267, Example 58

SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ncc4c3N(CCO)C2=O)c1F

InChI Key InChIKey=YTMJFPXFACYAGQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 301242   

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301242(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-(2-hydroxye...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent