BDBM301245 7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,7,9-tetrahydro-8H-imidazo[4',5':5,6]pyrido[4,3-d]pyrimidin-8-one::US10131667, Example 61::US11053246, Example 61::US9611267, Example 61

SMILES COc1cc(OC)c(F)c(N2Cc3cnc4[nH]cnc4c3N(C)C2=O)c1F

InChI Key InChIKey=TZMMPGOEQVZVGB-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 301245   

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM301245(7-(2,6-difluoro-3,5-dimethoxyphenyl)-9-methyl-3,6,...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent