BDBM303785 4-{[2-(10′-Chloro-2′,5′-dioxo-5′,6′-dihydrospiro[cyclopropane-1,7′-pyrido[3,4-d][2]benzazepine]-3′(2′H)-yl)butanoyl]amino}benzoic acid (Stereoisomer Mixture)::US10138236, Example 3

SMILES CCC(C(=O)Nc1ccc(cc1)C(O)=O)n1cc2c(cc1=O)-c1cc(Cl)ccc1C1(CC1)NC2=O

InChI Key InChIKey=KCGMSSQFQFMUQQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303785   

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM303785(4-{[2-(10′-Chloro-2′,5′-dioxo-5&...)
Affinity DataIC50: 180nMAssay Description:The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM303785(4-{[2-(10′-Chloro-2′,5′-dioxo-5&...)
Affinity DataIC50: 5.00E+4nMAssay Description:o determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent