BDBM303812 2-(11′-Chloro-2′,5′-dioxo-2′,5′,6′,8′-tetrahydro-3′H-spiro[cyclopropane-1,7′-pyrido[3,4-e][3]benzazocine]-3′-yl)-N-(2-methyl-2H-indazol-5-yl)-3-phenylpropanamide (Stereoisomer Mixture)::US10138236, Example 30

SMILES Cn1cc2cc(NC(=O)C(Cc3ccccc3)n3cc4c(cc3=O)-c3cc(Cl)ccc3CC3(CC3)NC4=O)ccc2n1

InChI Key InChIKey=NCOTWGDMTUCKSK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303812   

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM303812(2-(11′-Chloro-2′,5′-dioxo-2̸...)
Affinity DataIC50: 4.5nMAssay Description:The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM303812(2-(11′-Chloro-2′,5′-dioxo-2̸...)
Affinity DataIC50: 45nMAssay Description:o determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent