BDBM304425 (R)-2-(4-(4-(5-(hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-yl)-3-isopropylpiperazin-1-yl)-2-(methylsulfonyl)phenyl)thiazole-4-carbonitrile::US10144715, Compound 11-12

SMILES CC(C)[C@@H]1CN(CCN1c1ncc(CO)c(n1)C(F)(F)F)c1ccc(-c2nc(cs2)C#N)c(c1)S(C)(=O)=O

InChI Key InChIKey=MQKQOJAXHYOTRU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304425   

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304425((R)-2-(4-(4-(5-(hydroxymethyl)-4-(trifluoromethyl)...)
Affinity DataKi:  8nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304425((R)-2-(4-(4-(5-(hydroxymethyl)-4-(trifluoromethyl)...)
Affinity DataKi:  194nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent